Drug interactions
Tacrolimus + Triamcinolone acetonide injectable
Severity: Moderate
Tacrolimus and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and tacrolimus share CYP3A4 metabolism, so tacrolimus levels may change, and the combination adds immunosuppression and hyperglycemia risk. Systemic exposure from a depot injection can last for weeks.
What this interaction means in plain words
Tacrolimus and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for or modulation of CYP3A4 metabolism, plus additive immunosuppression.
What to do
Monitor tacrolimus trough levels, blood glucose and signs of infection after injection and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Tacrolimus and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and tacrolimus share CYP3A4 metabolism, so tacrolimus levels may change, and the combination adds immunosuppression and hyperglycemia risk. Systemic exposure from a depot injection can last for weeks.
How serious is the interaction between Tacrolimus and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels, blood glucose and signs of infection after injection and adjust the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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