Drug interactions
Tacrolimus + Trifluoperazine
Severity: Moderate
Tacrolimus and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes, particularly with electrolyte disturbances or other risk factors. The legacy direction of effect is inaccurate, as both drugs prolong rather than shorten QTc.
What this interaction means in plain words
Tacrolimus and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects (hERG potassium channel blockade).
What to do
Obtain a baseline ECG and repeat after initiation, and correct potassium and magnesium. Consider an alternative antipsychotic with less QT effect if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Trifluoperazine?
MediHelp rates the interaction as moderate. Tacrolimus and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes, particularly with electrolyte disturbances or other risk factors. The legacy direction of effect is inaccurate, as both drugs prolong rather than shorten QTc.
How serious is the interaction between Tacrolimus and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after initiation, and correct potassium and magnesium. Consider an alternative antipsychotic with less QT effect if the QTc becomes markedly prolonged.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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