Drug interactions
Tacrolimus + Typhoid polysaccharide vaccine
Severity: Moderate
Tacrolimus and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may weaken the antibody response to the inactivated Vi typhoid vaccine. It is non-live and can be given, but protection may be incomplete.
What this interaction means in plain words
Tacrolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell dependent immune responses.
What to do
Use the inactivated vaccine, give it at least two weeks before travel, and reinforce food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Tacrolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may weaken the antibody response to the inactivated Vi typhoid vaccine. It is non-live and can be given, but protection may be incomplete.
How serious is the interaction between Tacrolimus and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated vaccine, give it at least two weeks before travel, and reinforce food and water precautions.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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