Drug interactions
Tacrolimus + Typhoid vaccine live
Severity: Contraindicated
Tacrolimus and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in immunosuppressed patients on tacrolimus. The vaccine response may also be reduced.
What this interaction means in plain words
Tacrolimus and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Calcineurin inhibitor immunosuppression impairs clearance of live attenuated organisms.
What to do
Avoid the live oral typhoid vaccine in patients on tacrolimus and use the inactivated Vi polysaccharide vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Tacrolimus and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral live typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in immunosuppressed patients on tacrolimus. The vaccine response may also be reduced.
How serious is the interaction between Tacrolimus and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral typhoid vaccine in patients on tacrolimus and use the inactivated Vi polysaccharide vaccine instead.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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