Drug interactions
Tacrolimus + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Tacrolimus and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, and vilanterol, a long-acting beta-agonist, may add to cardiovascular effects and QT prolongation. Systemic exposure from the inhaled dose is low, so the clinical effect is usually modest, though susceptible patients may be at risk.
What this interaction means in plain words
Tacrolimus and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac effects, with possible hypokalemia from the beta-agonist.
What to do
Monitor ECG and serum potassium and magnesium in patients with cardiac risk factors or other QT-prolonging drugs. Counsel patients to report palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Tacrolimus and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, and vilanterol, a long-acting beta-agonist, may add to cardiovascular effects and QT prolongation. Systemic exposure from the inhaled dose is low, so the clinical effect is usually modest, though susceptible patients may be at risk.
How serious is the interaction between Tacrolimus and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium in patients with cardiac risk factors or other QT-prolonging drugs. Counsel patients to report palpitations or syncope.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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