Drug interactions
Tacrolimus + Venlafaxine
Severity: Moderate
Tacrolimus and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine and tacrolimus each have some potential to prolong the QT interval, so combining them may add to arrhythmia risk. The clinical significance is greatest in patients with other risk factors for torsades de pointes.
What this interaction means in plain words
Tacrolimus and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check an ECG at baseline and after changes in dose, and keep potassium and magnesium within normal range. Review other QT-prolonging drugs the patient takes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Venlafaxine?
MediHelp rates the interaction as moderate. Tacrolimus and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine and tacrolimus each have some potential to prolong the QT interval, so combining them may add to arrhythmia risk. The clinical significance is greatest in patients with other risk factors for torsades de pointes.
How serious is the interaction between Tacrolimus and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and after changes in dose, and keep potassium and magnesium within normal range. Review other QT-prolonging drugs the patient takes.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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