Drug interactions
Tacrolimus + Vincristine liposomal
Severity: Moderate
Tacrolimus and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein and could theoretically increase vincristine exposure, raising the risk of neurotoxicity. The clinical evidence for the liposomal formulation is limited.
What this interaction means in plain words
Tacrolimus and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tacrolimus inhibition of P-glycoprotein efflux of vincristine.
What to do
Monitor for peripheral neuropathy, constipation and other signs of vincristine toxicity. Reduce or delay the vincristine dose if neurotoxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Vincristine liposomal?
MediHelp rates the interaction as moderate. Tacrolimus and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein and could theoretically increase vincristine exposure, raising the risk of neurotoxicity. The clinical evidence for the liposomal formulation is limited.
How serious is the interaction between Tacrolimus and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and other signs of vincristine toxicity. Reduce or delay the vincristine dose if neurotoxicity emerges.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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