Drug interactions
Tacrolimus + Zanubrutinib
Severity: Moderate
Tacrolimus and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib may reduce tacrolimus concentrations, which could risk under-immunosuppression and graft rejection in transplant patients.
What this interaction means in plain words
Tacrolimus and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Zanubrutinib belongs to Oncology.
Why it happens
Zanubrutinib weakly induces CYP3A, increasing tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels when starting or stopping zanubrutinib and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zanubrutinib
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Zanubrutinib?
MediHelp rates the interaction as moderate. Tacrolimus and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zanubrutinib may reduce tacrolimus concentrations, which could risk under-immunosuppression and graft rejection in transplant patients.
How serious is the interaction between Tacrolimus and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels when starting or stopping zanubrutinib and adjust the dose accordingly.
What other medicines interact with Zanubrutinib?
MediHelp also lists interactions of Zanubrutinib with, for example, Alteplase, Amobarbital, Apalutamide. The full list is on the Zanubrutinib page.
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