Drug interactions
Tacrolimus + Zoster vaccine recombinant
Severity: Moderate
Tacrolimus and Zoster vaccine recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus suppresses T-cell responses and may blunt the immune response to the recombinant zoster vaccine. The vaccine is non-live and can be given, but protection may be reduced.
What this interaction means in plain words
Tacrolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism due to immunosuppression reducing vaccine-induced immune response.
What to do
Vaccinate when clinically indicated, ideally before starting immunosuppression or when dosing is at its lowest. Do not delay vaccination in patients who need ongoing therapy, and continue to watch for zoster.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Zoster vaccine recombinant?
MediHelp rates the interaction as moderate. Tacrolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus suppresses T-cell responses and may blunt the immune response to the recombinant zoster vaccine. The vaccine is non-live and can be given, but protection may be reduced.
How serious is the interaction between Tacrolimus and Zoster vaccine recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when clinically indicated, ideally before starting immunosuppression or when dosing is at its lowest. Do not delay vaccination in patients who need ongoing therapy, and continue to watch for zoster.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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