Drug interactions
Tadalafil + Tamsulosin
Severity: Moderate
Tadalafil and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can cause additive vasodilation with a drop in blood pressure, dizziness and syncope. Tadalafil is labeled with a caution for use alongside alpha-blockers other than tamsulosin 0.4 mg, and this pairing is widely used in BPH with erectile dysfunction.
What this interaction means in plain words
Tadalafil and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Tamsulosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 adrenergic blockade and PDE5 inhibition.
What to do
Establish a stable tamsulosin dose before adding tadalafil and counsel on orthostatic symptoms. Monitor blood pressure, especially at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Tadalafil with Tamsulosin?
MediHelp rates the interaction as moderate. Tadalafil and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can cause additive vasodilation with a drop in blood pressure, dizziness and syncope. Tadalafil is labeled with a caution for use alongside alpha-blockers other than tamsulosin 0.4 mg, and this pairing is widely used in BPH with erectile dysfunction.
How serious is the interaction between Tadalafil and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Establish a stable tamsulosin dose before adding tadalafil and counsel on orthostatic symptoms. Monitor blood pressure, especially at initiation.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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