Drug interactions
Tadalafil + Vardenafil
Severity: Major
Tadalafil and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil and tadalafil are both PDE5 inhibitors, so taking them together is therapeutic duplication with no added benefit. It increases the chance of hypotension, flushing, headache, visual disturbance and priapism.
What this interaction means in plain words
Tadalafil and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tadalafil belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic inhibition of phosphodiesterase type 5 leading to excessive vasodilation.
What to do
Do not use two PDE5 inhibitors concurrently; choose a single agent. If switching, allow the first drug to clear before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Tadalafil with Vardenafil?
MediHelp rates the interaction as major. Tadalafil and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vardenafil and tadalafil are both PDE5 inhibitors, so taking them together is therapeutic duplication with no added benefit. It increases the chance of hypotension, flushing, headache, visual disturbance and priapism.
How serious is the interaction between Tadalafil and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two PDE5 inhibitors concurrently; choose a single agent. If switching, allow the first drug to clear before starting the other.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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