Drug interactions
Tadalafil + Zafirlukast
Severity: Minor
Tadalafil and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is cleared mainly by CYP3A4, and zafirlukast may modestly raise its exposure. This may increase headache, flushing, dizziness and hypotension.
What this interaction means in plain words
Tadalafil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tadalafil belongs to Genitourinary; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated tadalafil metabolism by zafirlukast.
What to do
Monitor tolerability and blood pressure. Use the lower tadalafil dose range if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Tadalafil with Zafirlukast?
MediHelp rates the interaction as minor. Tadalafil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil is cleared mainly by CYP3A4, and zafirlukast may modestly raise its exposure. This may increase headache, flushing, dizziness and hypotension.
How serious is the interaction between Tadalafil and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability and blood pressure. Use the lower tadalafil dose range if adverse effects occur.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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