Drug interactions
Tafamidis + Tenofovir disoproxil
Severity: Minor
Tafamidis and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and might raise exposure to BCRP substrates. Tenofovir has only limited BCRP dependence, so a clinically important effect is not expected.
What this interaction means in plain words
Tafamidis and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
In vitro BCRP inhibition by tafamidis could increase tenofovir absorption.
What to do
No dose change is needed; monitor renal function as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Tafamidis with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Tafamidis and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and might raise exposure to BCRP substrates. Tenofovir has only limited BCRP dependence, so a clinically important effect is not expected.
How serious is the interaction between Tafamidis and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor renal function as routine.
What other medicines interact with Tafamidis?
MediHelp also lists interactions of Tafamidis with, for example, Apixaban, Atorvastatin, Methotrexate. The full list is on the Tafamidis page.
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