Drug interactions
Talquetamab + Theophylline
Severity: Moderate
Talquetamab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, and the released cytokines temporarily suppress CYP enzymes. Theophylline levels may rise and cause toxicity such as arrhythmias, seizures or vomiting, mostly during step-up dosing and for some days afterwards.
What this interaction means in plain words
Talquetamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Talquetamab belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Cytokine release (notably IL-6) downregulates CYP1A2 and CYP3A4 activity, reducing theophylline clearance.
What to do
Monitor theophylline concentrations and signs of toxicity during step-up dosing and for about two weeks after the first treatment dose, and during any CRS episode. Reduce the theophylline dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Talquetamab with Theophylline?
MediHelp rates the interaction as moderate. Talquetamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, and the released cytokines temporarily suppress CYP enzymes. Theophylline levels may rise and cause toxicity such as arrhythmias, seizures or vomiting, mostly during step-up dosing and for some days afterwards.
How serious is the interaction between Talquetamab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline concentrations and signs of toxicity during step-up dosing and for about two weeks after the first treatment dose, and during any CRS episode. Reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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