Drug interactions
Tapentadol + Thiothixene
Severity: Moderate
Tapentadol and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic, and with tapentadol it may increase drowsiness, dizziness, hypotension and respiratory depression. Tapentadol also lowers the seizure threshold, as do antipsychotics, which adds some further risk.
What this interaction means in plain words
Tapentadol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects of an opioid and an antipsychotic.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiratory status, especially at initiation or dose increases. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Tapentadol with Thiothixene?
MediHelp rates the interaction as moderate. Tapentadol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic, and with tapentadol it may increase drowsiness, dizziness, hypotension and respiratory depression. Tapentadol also lowers the seizure threshold, as do antipsychotics, which adds some further risk.
How serious is the interaction between Tapentadol and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiratory status, especially at initiation or dose increases. Advise against alcohol and driving.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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