Drug interactions
Tazemetostat + Venlafaxine
Severity: Minor
Tazemetostat and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Because CYP3A4 is a minor pathway for venlafaxine, a clinically meaningful change is unlikely.
What this interaction means in plain words
Tazemetostat and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction may modestly increase venlafaxine clearance.
What to do
No dose change is usually required. Monitor for reduced antidepressant response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Venlafaxine?
MediHelp rates the interaction as minor. Tazemetostat and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Because CYP3A4 is a minor pathway for venlafaxine, a clinically meaningful change is unlikely.
How serious is the interaction between Tazemetostat and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for reduced antidepressant response.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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