Drug interactions
Tecovirimat + Ulipristal
Severity: Moderate
Tecovirimat and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower ulipristal exposure, possibly reducing emergency contraception efficacy.
What this interaction means in plain words
Tecovirimat and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 induction by tecovirimat increases ulipristal metabolism.
What to do
Consider a copper IUD as emergency contraception. If ulipristal is used, counsel on a possible reduction in efficacy and follow-up for pregnancy if menses are delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tecovirimat and Ulipristal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Tecovirimat with Ulipristal?
MediHelp rates the interaction as moderate. Tecovirimat and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat is a weak CYP3A4 inducer and may modestly lower ulipristal exposure, possibly reducing emergency contraception efficacy.
How serious is the interaction between Tecovirimat and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper IUD as emergency contraception. If ulipristal is used, counsel on a possible reduction in efficacy and follow-up for pregnancy if menses are delayed.
What other medicines interact with Tecovirimat?
MediHelp also lists interactions of Tecovirimat with, for example, Bosentan, Cyclosporin, Darunavir. The full list is on the Tecovirimat page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
