Drug interactions
Telavancin + Warfarin
Severity: Moderate
Telavancin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telavancin can interfere with coagulation laboratory tests, falsely prolonging PT/INR and aPTT for hours after dosing. This can make warfarin monitoring unreliable and may lead to inappropriate dose changes.
What this interaction means in plain words
Telavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telavancin belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Telavancin interferes with phospholipid-dependent coagulation assay reagents, causing artifactual prolongation rather than a true change in warfarin effect.
What to do
Draw blood for INR as close as possible before the next telavancin dose, or use a chromogenic factor X assay. Interpret INR changes cautiously and watch for clinical signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Telavancin with Warfarin?
MediHelp rates the interaction as moderate. Telavancin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telavancin can interfere with coagulation laboratory tests, falsely prolonging PT/INR and aPTT for hours after dosing. This can make warfarin monitoring unreliable and may lead to inappropriate dose changes.
How serious is the interaction between Telavancin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Draw blood for INR as close as possible before the next telavancin dose, or use a chromogenic factor X assay. Interpret INR changes cautiously and watch for clinical signs of bleeding.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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