Drug interactions
Telmisartan-amlodipine + Trofinetide
Severity: Moderate
Telmisartan-amlodipine and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1/1B3 in vitro and may raise exposure to sensitive substrates. Telmisartan is a substrate of hepatic uptake, so higher levels with exaggerated blood pressure lowering are possible, though clinical data are lacking.
What this interaction means in plain words
Telmisartan-amlodipine and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan-amlodipine belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Trofinetide inhibits OATP1B1/1B3 hepatic uptake, potentially increasing telmisartan exposure.
What to do
Monitor blood pressure and renal function if used together. Reduce telmisartan dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Telmisartan-amlodipine with Trofinetide?
MediHelp rates the interaction as moderate. Telmisartan-amlodipine and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1/1B3 in vitro and may raise exposure to sensitive substrates. Telmisartan is a substrate of hepatic uptake, so higher levels with exaggerated blood pressure lowering are possible, though clinical data are lacking.
How serious is the interaction between Telmisartan-amlodipine and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if used together. Reduce telmisartan dose if hypotension or adverse effects occur.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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