Drug interactions
Telmisartan + Trofinetide
Severity: Moderate
Telmisartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1/1B3 and raise exposure to substrates of these transporters. Telmisartan uptake is partly OATP-mediated, so exposure may increase modestly, with possible hypotension or renal effects.
What this interaction means in plain words
Telmisartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Possible inhibition of hepatic OATP1B1/1B3 uptake by trofinetide, raising telmisartan levels.
What to do
Monitor blood pressure and renal function when combining them. Reduce the telmisartan dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Telmisartan with Trofinetide?
MediHelp rates the interaction as moderate. Telmisartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1/1B3 and raise exposure to substrates of these transporters. Telmisartan uptake is partly OATP-mediated, so exposure may increase modestly, with possible hypotension or renal effects.
How serious is the interaction between Telmisartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when combining them. Reduce the telmisartan dose if hypotension develops.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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