Drug interactions
Temazepam + Topiramate
Severity: Moderate
Temazepam and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam and topiramate each cause drowsiness and psychomotor slowing, so the combination can intensify sedation, dizziness and impaired coordination. Older patients are at higher risk of falls and confusion.
What this interaction means in plain words
Temazepam and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temazepam belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABAergic enhancement.
What to do
Use the lowest effective temazepam dose and monitor for daytime sedation and cognitive effects. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Topiramate?
MediHelp rates the interaction as moderate. Temazepam and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam and topiramate each cause drowsiness and psychomotor slowing, so the combination can intensify sedation, dizziness and impaired coordination. Older patients are at higher risk of falls and confusion.
How serious is the interaction between Temazepam and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for daytime sedation and cognitive effects. Avoid alcohol and counsel on driving.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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