Drug interactions
Temazepam + Triprolidine
Severity: Moderate
Temazepam and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a sedating antihistamine with temazepam increases drowsiness, impaired psychomotor performance and next-day impairment. Falls are a particular concern in older adults.
What this interaction means in plain words
Temazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temazepam belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 blockade and GABA-A potentiation.
What to do
Avoid combining where possible and counsel against driving and alcohol. Consider a lower temazepam dose in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Triprolidine?
MediHelp rates the interaction as moderate. Temazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a sedating antihistamine with temazepam increases drowsiness, impaired psychomotor performance and next-day impairment. Falls are a particular concern in older adults.
How serious is the interaction between Temazepam and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and counsel against driving and alcohol. Consider a lower temazepam dose in older patients.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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