Drug interactions
Temazepam + Zolpidem
Severity: Major
Temazepam and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking zolpidem with temazepam increases sedation and the risk of psychomotor impairment, falls, amnesia and respiratory depression. Using two hypnotics together offers little benefit and adds risk.
What this interaction means in plain words
Temazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Temazepam belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from two GABA-A receptor positive modulators.
What to do
Avoid concurrent use of the two hypnotics; if unavoidable, use the lowest effective doses and monitor for oversedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Zolpidem?
MediHelp rates the interaction as major. Temazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking zolpidem with temazepam increases sedation and the risk of psychomotor impairment, falls, amnesia and respiratory depression. Using two hypnotics together offers little benefit and adds risk.
How serious is the interaction between Temazepam and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two hypnotics; if unavoidable, use the lowest effective doses and monitor for oversedation and respiratory depression.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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