Drug interactions
Terazosin + Tolfenamic acid
Severity: Moderate
Terazosin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of antihypertensives, which may reduce the control achieved with terazosin when used for hypertension. The effect is variable and generally modest.
What this interaction means in plain words
Terazosin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terazosin belongs to Genitourinary; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and fluid retention and raises vascular resistance, opposing antihypertensive action.
What to do
Monitor blood pressure when the NSAID is started, continued or stopped. Use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Terazosin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Terazosin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of antihypertensives, which may reduce the control achieved with terazosin when used for hypertension. The effect is variable and generally modest.
How serious is the interaction between Terazosin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, continued or stopped. Use the lowest effective dose for the shortest time.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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