Drug interactions
Terazosin + Vardenafil
Severity: Major
Terazosin and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining vardenafil with terazosin can produce additive blood pressure lowering, leading to symptomatic orthostatic hypotension or fainting. The risk is highest at treatment initiation or after dose increases.
What this interaction means in plain words
Terazosin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Terazosin belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 adrenergic blockade and PDE5 inhibition.
What to do
Avoid the combination where possible; if needed, stabilize the patient on terazosin first and start vardenafil at the lowest dose. Monitor orthostatic blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Terazosin with Vardenafil?
MediHelp rates the interaction as major. Terazosin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining vardenafil with terazosin can produce additive blood pressure lowering, leading to symptomatic orthostatic hypotension or fainting. The risk is highest at treatment initiation or after dose increases.
How serious is the interaction between Terazosin and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, stabilize the patient on terazosin first and start vardenafil at the lowest dose. Monitor orthostatic blood pressure.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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