Drug interactions
Terazosin + Verapamil
Severity: Moderate
Terazosin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with verapamil can cause additive blood pressure reduction, leading to symptomatic hypotension and dizziness. Verapamil may also modestly raise alpha-blocker exposure by inhibiting CYP3A4, as shown with prazosin.
What this interaction means in plain words
Terazosin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terazosin belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and calcium channel blockade, with possible pharmacokinetic contribution from verapamil.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate gradually and reduce the alpha-blocker dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Terazosin with Verapamil?
MediHelp rates the interaction as moderate. Terazosin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with verapamil can cause additive blood pressure reduction, leading to symptomatic hypotension and dizziness. Verapamil may also modestly raise alpha-blocker exposure by inhibiting CYP3A4, as shown with prazosin.
How serious is the interaction between Terazosin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate gradually and reduce the alpha-blocker dose if hypotension occurs.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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