Drug interactions
Tezacaftor + Voriconazole
Severity: Moderate
Tezacaftor and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises tezacaftor exposure, increasing the chance of adverse effects. Tezacaftor is given with ivacaftor, whose exposure is also increased by strong CYP3A inhibitors.
What this interaction means in plain words
Tezacaftor and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces tezacaftor and ivacaftor metabolism.
What to do
Reduce tezacaftor/ivacaftor to the labeled reduced-frequency schedule for strong CYP3A inhibitors, with the ivacaftor-only doses on the alternate days. Monitor for adverse effects and liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Tezacaftor with Voriconazole?
MediHelp rates the interaction as moderate. Tezacaftor and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises tezacaftor exposure, increasing the chance of adverse effects. Tezacaftor is given with ivacaftor, whose exposure is also increased by strong CYP3A inhibitors.
How serious is the interaction between Tezacaftor and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce tezacaftor/ivacaftor to the labeled reduced-frequency schedule for strong CYP3A inhibitors, with the ivacaftor-only doses on the alternate days. Monitor for adverse effects and liver enzymes.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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