Drug interactions
Theophylline + Trofinetide
Severity: Minor
Theophylline and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor, but theophylline is cleared mainly by CYP1A2. A clinically significant rise in theophylline concentration is unlikely.
What this interaction means in plain words
Theophylline and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Theophylline belongs to Respiratory; Trofinetide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by trofinetide could slightly reduce the minor CYP3A4 pathway of theophylline.
What to do
No routine adjustment is needed; monitor for theophylline toxicity if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Theophylline and Trofinetide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Theophylline with Trofinetide?
MediHelp rates the interaction as minor. Theophylline and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide is a weak CYP3A4 inhibitor, but theophylline is cleared mainly by CYP1A2. A clinically significant rise in theophylline concentration is unlikely.
How serious is the interaction between Theophylline and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for theophylline toxicity if symptoms occur.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
