Drug interactions
Thioguanine + Trastuzumab deruxtecan
Severity: Moderate
Thioguanine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and thioguanine is myelosuppressive. Together they increase the risk of severe neutropenia and infection.
What this interaction means in plain words
Thioguanine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thioguanine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and the antimetabolite.
What to do
Monitor complete blood counts frequently and dose-modify for neutropenia; treat febrile neutropenia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioguanine
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Thioguanine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Thioguanine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and thioguanine is myelosuppressive. Together they increase the risk of severe neutropenia and infection.
How serious is the interaction between Thioguanine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and dose-modify for neutropenia; treat febrile neutropenia promptly.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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