Drug interactions
Thioridazine + Trandolapril
Severity: Moderate
Thioridazine and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has strong alpha-blocking activity and may cause orthostatic hypotension that adds to the effect of trandolapril. Dizziness, syncope and falls are the main concerns, especially in older adults.
What this interaction means in plain words
Thioridazine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thioridazine belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Additive hypotension from phenothiazine alpha-blockade and ACE inhibition.
What to do
Monitor blood pressure including standing values, and reduce the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Trandolapril?
MediHelp rates the interaction as moderate. Thioridazine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine has strong alpha-blocking activity and may cause orthostatic hypotension that adds to the effect of trandolapril. Dizziness, syncope and falls are the main concerns, especially in older adults.
How serious is the interaction between Thioridazine and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing values, and reduce the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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