Drug interactions
Thioridazine + Tretinoin
Severity: Minor
Thioridazine and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both phenothiazines and systemic tretinoin can cause photosensitivity, so combined use may increase sunburn-like reactions. The interaction is mainly additive skin sensitivity and usually manageable.
What this interaction means in plain words
Thioridazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Thioridazine belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects of both drugs.
What to do
Advise sun protection, protective clothing and sunscreen, and counsel patients to report skin reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Thioridazine with Tretinoin?
MediHelp rates the interaction as minor. Thioridazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both phenothiazines and systemic tretinoin can cause photosensitivity, so combined use may increase sunburn-like reactions. The interaction is mainly additive skin sensitivity and usually manageable.
How serious is the interaction between Thioridazine and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun protection, protective clothing and sunscreen, and counsel patients to report skin reactions.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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