Drug interactions
Thioridazine + Vandetanib
Severity: Contraindicated
Thioridazine and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes substantial QT prolongation and can lead to torsades de pointes and sudden death. Adding thioridazine, which also prolongs QT, greatly increases that risk.
What this interaction means in plain words
Thioridazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Thioridazine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not use together; switch to an antipsychotic without QT liability. Monitor ECG and electrolytes during vandetanib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Thioridazine with Vandetanib?
MediHelp rates the interaction as contraindicated. Thioridazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes substantial QT prolongation and can lead to torsades de pointes and sudden death. Adding thioridazine, which also prolongs QT, greatly increases that risk.
How serious is the interaction between Thioridazine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; switch to an antipsychotic without QT liability. Monitor ECG and electrolytes during vandetanib therapy.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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