Drug interactions
Tiagabine + Voriconazole
Severity: Moderate
Tiagabine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is metabolized mainly by CYP3A4, so voriconazole can raise its concentrations. This may increase dizziness, somnolence, tremor and risk of confusion or seizures from toxicity.
What this interaction means in plain words
Tiagabine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of tiagabine.
What to do
Monitor for CNS adverse effects and consider reducing the tiagabine dose when voriconazole is started. Reassess dose when voriconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Tiagabine with Voriconazole?
MediHelp rates the interaction as moderate. Tiagabine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is metabolized mainly by CYP3A4, so voriconazole can raise its concentrations. This may increase dizziness, somnolence, tremor and risk of confusion or seizures from toxicity.
How serious is the interaction between Tiagabine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and consider reducing the tiagabine dose when voriconazole is started. Reassess dose when voriconazole is stopped.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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