Drug interactions
Ticagrelor + Tirofiban
Severity: Major
Ticagrelor and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor combined with tirofiban intensifies platelet inhibition and increases bleeding risk. It is used in selected PCI settings.
What this interaction means in plain words
Ticagrelor and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ticagrelor belongs to Cardiovascular; Tirofiban belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects via P2Y12 and GP IIb/IIIa blockade.
What to do
Use only for a clear indication, monitor platelets, hemoglobin and bleeding, and minimize infusion duration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Tirofiban
Frequently asked questions
Can I take Ticagrelor with Tirofiban?
MediHelp rates the interaction as major. Ticagrelor and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticagrelor combined with tirofiban intensifies platelet inhibition and increases bleeding risk. It is used in selected PCI settings.
How serious is the interaction between Ticagrelor and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only for a clear indication, monitor platelets, hemoglobin and bleeding, and minimize infusion duration.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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