Drug interactions
Timolol + Tolfenamic acid
Severity: Moderate
Timolol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers with prolonged use. They may also impair renal function and fluid balance, worsening blood pressure control.
What this interaction means in plain words
Timolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Timolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and opposes beta-blocker antihypertensive action.
What to do
Monitor blood pressure if NSAID use continues beyond a few days. Use the lowest effective NSAID dose for the shortest time, or consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Timolol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Timolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers with prolonged use. They may also impair renal function and fluid balance, worsening blood pressure control.
How serious is the interaction between Timolol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if NSAID use continues beyond a few days. Use the lowest effective NSAID dose for the shortest time, or consider an alternative analgesic.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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