Drug interactions
Timolol + Treprostinil
Severity: Moderate
Timolol and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with a beta-blocker such as timolol can increase the risk of hypotension. Systemic exposure to timolol from eye drops is lower but can still be relevant.
What this interaction means in plain words
Timolol and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Timolol belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive hypotensive effects: prostacyclin analog vasodilation plus beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or titrating treprostinil in patients taking timolol, and reduce the dose of the antihypertensive if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Timolol with Treprostinil?
MediHelp rates the interaction as moderate. Timolol and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with a beta-blocker such as timolol can increase the risk of hypotension. Systemic exposure to timolol from eye drops is lower but can still be relevant.
How serious is the interaction between Timolol and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating treprostinil in patients taking timolol, and reduce the dose of the antihypertensive if symptomatic hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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