Drug interactions
Timolol + Umeclidinium-vilanterol
Severity: Major
Timolol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol is a non-selective beta-blocker that opposes vilanterol and may precipitate bronchospasm. Even ophthalmic timolol can be absorbed enough to worsen airway obstruction in susceptible patients.
What this interaction means in plain words
Timolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Timolol belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid timolol in patients with COPD or asthma on this inhaler and choose an alternative, such as a cardioselective beta-blocker or a non-beta-blocker eye drop. If used, monitor respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Timolol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Timolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic timolol is a non-selective beta-blocker that opposes vilanterol and may precipitate bronchospasm. Even ophthalmic timolol can be absorbed enough to worsen airway obstruction in susceptible patients.
How serious is the interaction between Timolol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid timolol in patients with COPD or asthma on this inhaler and choose an alternative, such as a cardioselective beta-blocker or a non-beta-blocker eye drop. If used, monitor respiratory status.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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