Drug interactions
Tiotropium + Tolterodine
Severity: Moderate
Tiotropium and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are muscarinic antagonists, so using them together increases anticholinergic adverse effects. These include dry mouth, constipation, urinary retention and blurred vision.
What this interaction means in plain words
Tiotropium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and visual symptoms. Consider a lower tolterodine dose or an alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Tolterodine
Frequently asked questions
Can I take Tiotropium with Tolterodine?
MediHelp rates the interaction as moderate. Tiotropium and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are muscarinic antagonists, so using them together increases anticholinergic adverse effects. These include dry mouth, constipation, urinary retention and blurred vision.
How serious is the interaction between Tiotropium and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and visual symptoms. Consider a lower tolterodine dose or an alternative if symptoms develop.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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