Drug interactions
Tipranavir + Ulipristal
Severity: Moderate
Tipranavir and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir has mixed CYP3A4 effects, but net inhibition is typical and may raise ulipristal concentrations. The clinical effect is uncertain and induction could also reduce efficacy.
What this interaction means in plain words
Tipranavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir-boosted tipranavir modulates CYP3A4, altering ulipristal metabolism.
What to do
Prefer a copper IUD as emergency contraception. If ulipristal is used, counsel on adverse effects and follow up for pregnancy if menses are delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Ulipristal?
MediHelp rates the interaction as moderate. Tipranavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir has mixed CYP3A4 effects, but net inhibition is typical and may raise ulipristal concentrations. The clinical effect is uncertain and induction could also reduce efficacy.
How serious is the interaction between Tipranavir and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a copper IUD as emergency contraception. If ulipristal is used, counsel on adverse effects and follow up for pregnancy if menses are delayed.
What other medicines interact with Tipranavir?
MediHelp also lists interactions of Tipranavir with, for example, Alfuzosin, Amiodarone, Atorvastatin. The full list is on the Tipranavir page.
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