Drug interactions
Tipranavir + Venlafaxine
Severity: Moderate
Tipranavir and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which inhibits CYP3A4 and CYP2D6 and may raise venlafaxine concentrations. This may increase dose-related adverse effects, including blood pressure elevation and serotonergic toxicity.
What this interaction means in plain words
Tipranavir and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Venlafaxine belongs to Central Nervous System.
Why it happens
Ritonavir-boosted inhibition of CYP2D6 and CYP3A4 reduces venlafaxine clearance.
What to do
Start venlafaxine at a low dose and titrate cautiously. Monitor blood pressure and for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Venlafaxine?
MediHelp rates the interaction as moderate. Tipranavir and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is given with ritonavir, which inhibits CYP3A4 and CYP2D6 and may raise venlafaxine concentrations. This may increase dose-related adverse effects, including blood pressure elevation and serotonergic toxicity.
How serious is the interaction between Tipranavir and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start venlafaxine at a low dose and titrate cautiously. Monitor blood pressure and for signs of serotonin toxicity.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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