Drug interactions
Tobramycin + Tolfenamic acid
Severity: Moderate
Tobramycin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels, an effect documented mainly in preterm neonates. Higher exposure increases the risk of nephrotoxicity and ototoxicity.
What this interaction means in plain words
Tobramycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tobramycin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin-dependent renal blood flow reduces aminoglycoside clearance.
What to do
Avoid concurrent NSAIDs in neonates and those with renal impairment; otherwise monitor tobramycin levels and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tobramycin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Tobramycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels, an effect documented mainly in preterm neonates. Higher exposure increases the risk of nephrotoxicity and ototoxicity.
How serious is the interaction between Tobramycin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAIDs in neonates and those with renal impairment; otherwise monitor tobramycin levels and creatinine.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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