Drug interactions
Tolazamide + Tolmetin
Severity: Moderate
Tolazamide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose lowering effect of sulfonylureas such as tolazamide, occasionally causing hypoglycemia. The evidence for tolmetin specifically is limited.
What this interaction means in plain words
Tolazamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolazamide belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and effects on prostaglandin-mediated insulin secretion; the mechanism is not well established.
What to do
Monitor blood glucose when starting or stopping tolmetin and warn the patient about hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Tolmetin?
MediHelp rates the interaction as moderate. Tolazamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose lowering effect of sulfonylureas such as tolazamide, occasionally causing hypoglycemia. The evidence for tolmetin specifically is limited.
How serious is the interaction between Tolazamide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tolmetin and warn the patient about hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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