Drug interactions
Tolazamide + Trandolapril
Severity: Moderate
Tolazamide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The risk is greatest early in therapy and in patients with renal impairment.
What this interaction means in plain words
Tolazamide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolazamide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through improved insulin sensitivity with ACE inhibition.
What to do
Monitor blood glucose when trandolapril is started or adjusted and lower the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Trandolapril?
MediHelp rates the interaction as moderate. Tolazamide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The risk is greatest early in therapy and in patients with renal impairment.
How serious is the interaction between Tolazamide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trandolapril is started or adjusted and lower the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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