Drug interactions
Tolazamide + Triamcinolone
Severity: Moderate
Tolazamide and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can reduce the effect of sulfonylureas such as tolazamide, resulting in poorer glycemic control. Glucose may rise for days after a depot triamcinolone injection.
What this interaction means in plain words
Tolazamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolazamide belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via corticosteroid-induced insulin resistance and increased hepatic gluconeogenesis.
What to do
Check blood glucose more often after triamcinolone and increase the antidiabetic dose if needed. Lower it again when the corticosteroid effect subsides to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tolazamide and Triamcinolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Tolazamide with Triamcinolone?
MediHelp rates the interaction as moderate. Tolazamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can reduce the effect of sulfonylureas such as tolazamide, resulting in poorer glycemic control. Glucose may rise for days after a depot triamcinolone injection.
How serious is the interaction between Tolazamide and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after triamcinolone and increase the antidiabetic dose if needed. Lower it again when the corticosteroid effect subsides to avoid hypoglycemia.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
