Drug interactions
Tolbutamide + Tolmetin
Severity: Moderate
Tolbutamide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the hypoglycemic effect of tolbutamide, with occasional reports of low blood glucose. Evidence for tolmetin is limited.
What this interaction means in plain words
Tolbutamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolbutamide belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement or reduced metabolism of the sulfonylurea; the mechanism is not clearly established.
What to do
Monitor blood glucose when starting or stopping tolmetin and counsel the patient on hypoglycemia symptoms. Reduce the tolbutamide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Tolmetin?
MediHelp rates the interaction as moderate. Tolbutamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the hypoglycemic effect of tolbutamide, with occasional reports of low blood glucose. Evidence for tolmetin is limited.
How serious is the interaction between Tolbutamide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tolmetin and counsel the patient on hypoglycemia symptoms. Reduce the tolbutamide dose if needed.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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