Drug interactions
Tolbutamide + Trandolapril
Severity: Moderate
Tolbutamide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mostly early in treatment or in patients with renal impairment.
What this interaction means in plain words
Tolbutamide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolbutamide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Pharmacodynamic synergism: ACE inhibition may improve insulin sensitivity and potentiate sulfonylurea hypoglycemic action.
What to do
Monitor blood glucose closely when starting or adjusting trandolapril, and reduce the tolbutamide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Trandolapril?
MediHelp rates the interaction as moderate. Tolbutamide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mostly early in treatment or in patients with renal impairment.
How serious is the interaction between Tolbutamide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting trandolapril, and reduce the tolbutamide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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