Drug interactions
Tolbutamide + Triamcinolone
Severity: Moderate
Tolbutamide and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can reduce the effect of tolbutamide, leading to poorer glycemic control. The effect is more pronounced with systemic or repeated depot dosing.
What this interaction means in plain words
Tolbutamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolbutamide belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via corticosteroid-induced insulin resistance and increased hepatic glucose output.
What to do
Monitor blood glucose more frequently after triamcinolone and adjust the sulfonylurea dose as needed. Re-evaluate the dose as the corticosteroid effect wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Triamcinolone?
MediHelp rates the interaction as moderate. Tolbutamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can reduce the effect of tolbutamide, leading to poorer glycemic control. The effect is more pronounced with systemic or repeated depot dosing.
How serious is the interaction between Tolbutamide and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after triamcinolone and adjust the sulfonylurea dose as needed. Re-evaluate the dose as the corticosteroid effect wanes.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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