Drug interactions
Tolfenamic acid + Tolmetin
Severity: Major
Tolfenamic acid and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together adds no therapeutic benefit and increases the risk of gastrointestinal ulceration, bleeding and renal toxicity. Hyperkalemia and fluid retention are also more likely.
What this interaction means in plain words
Tolfenamic acid and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tolfenamic acid belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive COX inhibition causing mucosal injury, platelet inhibition and reduced renal prostaglandin synthesis.
What to do
Avoid concurrent use of two systemic NSAIDs and choose a single agent at the lowest effective dose. Switch fully from one to the other rather than overlapping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolfenamic acid with Tolmetin?
MediHelp rates the interaction as major. Tolfenamic acid and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together adds no therapeutic benefit and increases the risk of gastrointestinal ulceration, bleeding and renal toxicity. Hyperkalemia and fluid retention are also more likely.
How serious is the interaction between Tolfenamic acid and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs and choose a single agent at the lowest effective dose. Switch fully from one to the other rather than overlapping.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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