Drug interactions
Tolfenamic acid + Trandolapril
Severity: Moderate
Tolfenamic acid and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid can reduce the blood pressure lowering effect of trandolapril. In dehydrated, elderly or renally impaired patients the combination can also impair kidney function and raise potassium.
What this interaction means in plain words
Tolfenamic acid and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolfenamic acid belongs to Musculoskeletal; Trandolapril belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis opposes ACE inhibitor vasodilation and reduces renal perfusion.
What to do
Limit NSAID use to the shortest effective course, and monitor blood pressure, creatinine and potassium in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolfenamic acid with Trandolapril?
MediHelp rates the interaction as moderate. Tolfenamic acid and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid can reduce the blood pressure lowering effect of trandolapril. In dehydrated, elderly or renally impaired patients the combination can also impair kidney function and raise potassium.
How serious is the interaction between Tolfenamic acid and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit NSAID use to the shortest effective course, and monitor blood pressure, creatinine and potassium in at-risk patients.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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