Drug interactions
Tolmetin + Vancomycin
Severity: Moderate
Tolmetin and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of vancomycin, leading to higher serum levels and greater nephrotoxicity risk. The effect has been described mainly in neonates.
What this interaction means in plain words
Tolmetin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolmetin belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced decreases in renal prostaglandin-dependent glomerular filtration reduce vancomycin elimination.
What to do
Monitor vancomycin trough or AUC levels and serum creatinine, especially in neonates and patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Tolmetin with Vancomycin?
MediHelp rates the interaction as moderate. Tolmetin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of vancomycin, leading to higher serum levels and greater nephrotoxicity risk. The effect has been described mainly in neonates.
How serious is the interaction between Tolmetin and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vancomycin trough or AUC levels and serum creatinine, especially in neonates and patients with renal impairment.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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